INSULIN--A PROBABLE GROSS MOLECULAR STRUCTURE
نویسندگان
چکیده
منابع مشابه
temperature and ph effects on insulin structure: a molecular dynamic approach
conclusions accordingly, it can be concluded that locally low temperatures and acidic conditions are the main suspected reasons for protein misfolding. results based on the study findings the low temperature, 0°c, and acidic condition change the structure more strongly than other mentioned conditions. the low temperature and acidic conditions seem to have the most misfolding effect on insulin s...
متن کاملThe biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma.
Because of the occurrence of two polypeptide chains in the insulin molecule, it has been proposed by several investigators, most recently by Givol et al.,I that it may be synthesized in vivo as a single large polypeptide chainwhich is converted byproteolysis to insulin after the native conformation has been established. This mechanism would undoubtedly ensure correct and efficient assembly in v...
متن کاملDigital Library: Gross Structure and Requirements (Report from a Workshop)
The overall workshop goals were: to define those digital library parameters which especially influence issues of access to, retrieval of, and interaction with information; to identify key problems which must be solved to make digital library service an effective reality; to identify a general structure or framework for integrating research and solutions; and to propose and encourage specific, h...
متن کاملThe molecular structure of Rv2074, a probable pyridoxine 5'-phosphate oxidase from Mycobacterium tuberculosis, at 1.6 angstroms resolution.
The crystal structure of a conserved hypothetical protein corresponding to open reading frame Rv2074 from Mycobacterium tuberculosis (Mtb) has been solved by the two-wavelength anomalous dispersion method. Refinement of the molecular structure at 1.6 angstroms resolution resulted in an R(work) of 0.178 and an R(free) of 0.204. The crystal asymmetric unit contains an Rv2074 monomer; however, the...
متن کاملA Molecular–Structure Hypothesis
The self-similar symmetry that occurs between atomic nuclei, biological growth structures, the solar system, globular clusters and spiral galaxies suggests that a similar pattern should characterize atomic and molecular structures. This possibility is explored in terms of the current molecular structure-hypothesis and its extension into four-dimensional space-time. It is concluded that a quantu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1963
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.49.1.74